In a message beginning "Dear President Obama", the 86-year-old monarch said: "I have been deeply shocked and saddened to learn of the dreadful loss of life today in Newtown, Connecticut; particularly the news that so many of the dead are children."
The gunman, named as Adam Lanza, 20, killed 20 small children and six teachers in the Friday shooting, after walking into a school in an idyllic Connecticut town wielding at least two sophisticated firearms.
这个名叫Adam Lanza 的枪手，今年20岁，在周五的枪击事件中，拿着至少两种武器走进了康涅狄格州的小学，杀死了20名儿童和6名老师。
He had earlier killed his mother, who was a teacher at the school.
The queen, who never gives interviews and normally restricts her public comment to events in Commonwealth nations, added: "Prince Philip joins me in extending our heartfelt sympathy to you and the American people at this difficult time.
"The thoughts and prayers of everyone in the United Kingdom and throughout the Commonwealth are with the families and friends of those killed and with all those who have been affected by today's events."